Volume 232, 2021

Lipid specificity of the immune effector perforin

Abstract

Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely ordered lipid rafts and externalizing negatively charged lipid species. The dense membrane packing lowers the capacity of perforin to bind, and the negatively charged lipids scavenge any residual protein before pore formation. Using atomic force microscopy on model membrane systems, we here provide insight into the molecular basis of perforin lipid specificity.

Graphical abstract: Lipid specificity of the immune effector perforin

Associated articles

Article information

Article type
Paper
Submitted
22 4月 2020
Accepted
13 8月 2020
First published
13 8月 2020
This article is Open Access
Creative Commons BY license

Faraday Discuss., 2021,232, 236-255

Lipid specificity of the immune effector perforin

A. W. Hodel, J. A. Rudd-Schmidt, J. A. Trapani, I. Voskoboinik and B. W. Hoogenboom, Faraday Discuss., 2021, 232, 236 DOI: 10.1039/D0FD00043D

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