Issue 62, 2021

Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness

Abstract

A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host–guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.

Graphical abstract: Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness

Supplementary files

Article information

Article type
Communication
Submitted
04 6月 2021
Accepted
29 6月 2021
First published
30 6月 2021

Chem. Commun., 2021,57, 7625-7628

Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness

S. Chao, Z. Shen, Y. Pei, Y. Lv, X. Chen, J. Ren, K. Yang and Z. Pei, Chem. Commun., 2021, 57, 7625 DOI: 10.1039/D1CC02959B

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