Issue 2, 2021

Design and synthesis of metabolic chemical reporters for the visualization and identification of glycoproteins

Abstract

Glycosylation events play an invaluable role in regulating cellular processes including enzymatic activity, immune recognition, protein stability, and cell–cell interactions. However, researchers have yet to realize the full range of glycan mediated biological functions due to a lack of appropriate chemical tools. Fortunately, the past 25 years has seen the emergence of modified sugar analogs, termed metabolic chemical reporters (MCRs), which are metabolized by endogenous enzymes to label complex glycan structures. Here, we review the major reporters for each class of glycosylation and highlight recent applications that have made a tremendous impact on the field of glycobiology.

Graphical abstract: Design and synthesis of metabolic chemical reporters for the visualization and identification of glycoproteins

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Article information

Article type
Review Article
Submitted
13 1月 2021
Accepted
11 2月 2021
First published
18 2月 2021
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2021,2, 306-321

Design and synthesis of metabolic chemical reporters for the visualization and identification of glycoproteins

N. J. Pedowitz and M. R. Pratt, RSC Chem. Biol., 2021, 2, 306 DOI: 10.1039/D1CB00010A

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