Issue 65, 2020

A sodium alginate-based sustained-release IPN hydrogel and its applications

Abstract

Interpenetrating polymer network (IPN) hydrogels are crosslinked by two or more polymer networks, providing free volume space in the three-dimensional network structure, and providing conditions for the sustained and controlled release of drugs. The IPN hydrogels based on the natural polymer sodium alginate can form a stable porous network structure. Due to its excellent biocompatibility, the loaded drug can be sustained to the maximum extent without affecting its pharmacological effect. Sodium alginate-based IPN hydrogels have broad application prospects in the field of sustained and controlled drug release. This paper begins with an overview of the formation of alginate-based IPN hydrogels; summarizes the types of alginate-based IPN hydrogels; and discusses the pharmaceutical applications of alginate-based IPN hydrogels. We aim to give an overview of the research on IPN hydrogels based on sodium alginate in sustained and controlled drug release systems.

Graphical abstract: A sodium alginate-based sustained-release IPN hydrogel and its applications

Article information

Article type
Review Article
Submitted
14 5月 2020
Accepted
19 10月 2020
First published
30 10月 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 39722-39730

A sodium alginate-based sustained-release IPN hydrogel and its applications

Z. Zou, B. Zhang, X. Nie, Y. Cheng, Z. Hu, M. Liao and S. Li, RSC Adv., 2020, 10, 39722 DOI: 10.1039/D0RA04316H

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