Issue 7, 2019

Examining tumor modulating effects of photobiomodulation therapy on head and neck squamous cell carcinomas

Abstract

Photobiomodulation (PBM) therapy is an effective method for preventing and managing oral mucositis (OM) in head and neck squamous cell carcinoma (HNSCC) patients undergoing radiotherapy alone or in combination with chemotherapy. However, the potential effects of PBM therapy on premalignant and malignant cells eventually present in the treatment site are yet unknown. The aim of this systematic review was to analyze the effects of PBM therapy on HNSCC. A literature search was conducted in four indexed databases as follows: MEDLINE/PubMed, EMBASE, Web of Science, and Scopus. The databases were reviewed for papers published up to and including in October 2018. In vitro and in vivo studies that investigated the effects of PBM therapy on HNSCC were selected. From the 852 initially gathered studies, 15 met the inclusion criteria (13 in vitro and 2 in vivo). Only three in vitro studies were noted to have a low risk of bias. The included data demonstrated wide variations of study designs, PBM therapy protocols, and study outcomes. Cell proliferation and viability were the primary evaluation outcome in the in vitro studies. Of the 13 in vitro studies, seven noted a positive effect of PBM therapy on inhibiting or preventing an effect on HNSCC tumor cells, while six studies saw increased proliferation. One in vivo study reported increased oral SCC (OSCC) progression, while the other observed reduced tumor progression. Overall, the data from the studies included in the present systematic review do not support a clear conclusion about the effects of PBM therapy on HNSCC cells.

Graphical abstract: Examining tumor modulating effects of photobiomodulation therapy on head and neck squamous cell carcinomas

Article information

Article type
Perspective
Submitted
12 3月 2019
Accepted
09 6月 2019
First published
10 6月 2019

Photochem. Photobiol. Sci., 2019,18, 1621-1637

Examining tumor modulating effects of photobiomodulation therapy on head and neck squamous cell carcinomas

F. M. Silveira, M. D. P. Paglioni, M. M. Marques, A. R. Santos-Silva, C. A. Migliorati, P. Arany and M. D. Martins, Photochem. Photobiol. Sci., 2019, 18, 1621 DOI: 10.1039/C9PP00120D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements