Issue 20, 2018

Electrochemical imaging of cells and tissues

Abstract

The technological and experimental progress in electrochemical imaging of biological specimens is discussed with a view on potential applications for skin cancer diagnostics, reproductive medicine and microbial testing. The electrochemical analysis of single cell activity inside cell cultures, 3D cellular aggregates and microtissues is based on the selective detection of electroactive species involved in biological functions. Electrochemical imaging strategies, based on nano/micrometric probes scanning over the sample and sensor array chips, respectively, can be made sensitive and selective without being affected by optical interference as many other microscopy techniques. The recent developments in microfabrication, electronics and cell culturing/tissue engineering have evolved in affordable and fast-sampling electrochemical imaging platforms. We believe that the topics discussed herein demonstrate the applicability of electrochemical imaging devices in many areas related to cellular functions.

Graphical abstract: Electrochemical imaging of cells and tissues

Article information

Article type
Minireview
Submitted
04 3月 2018
Accepted
09 4月 2018
First published
09 4月 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2018,9, 4546-4554

Electrochemical imaging of cells and tissues

T. Lin, S. Rapino, H. H. Girault and A. Lesch, Chem. Sci., 2018, 9, 4546 DOI: 10.1039/C8SC01035H

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