Issue 16, 2018

A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

Abstract

We herein disclose a Cu-catalyzed synthesis of 5-arylsubstituted 1,2,3-triazoles via an oxidative interrupted click reaction, using air as the sole terminal oxidant. The current protocol provides a novel method for the one-step construction of fully substituted triazoles in good yields under mild conditions, in which arylboronic acids are employed as aromatic sources to interrupt the cuprate–triazole intermediate for the first time.

Graphical abstract: A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

Supplementary files

Article information

Article type
Research Article
Submitted
13 6月 2018
Accepted
03 7月 2018
First published
04 7月 2018

Org. Chem. Front., 2018,5, 2463-2467

A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

X. Yu, J. Xu, Y. Zhou and Q. Song, Org. Chem. Front., 2018, 5, 2463 DOI: 10.1039/C8QO00590G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements