Issue 19, 2018

Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications

Abstract

Synthetic polypeptides derived from the ring-opening polymerization of N-carboxyanhydrides can spontaneously fold into stable secondary structures under specific environmental conditions. These secondary structures and their dynamic transitions play an important role in regulating the properties of polypeptides in self-assembly, catalysis, polymerization, and biomedical applications. Here, we review the current strategies to modulate the secondary structures, and highlight the conformation-specific dynamic properties of synthetic polypeptides and the corresponding materials. A number of mechanistic studies elucidating the role of secondary structures are discussed, aiming to provide insights into the new designs and applications of synthetic polypeptides. We aim for this article to bring to people's attention synthetic polymers with ordered conformations, which may exhibit association behaviors and material properties that are otherwise not found in polymers without stable secondary structures.

Graphical abstract: Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications

Article information

Article type
Review Article
Submitted
31 1月 2018
First published
03 9月 2018

Chem. Soc. Rev., 2018,47, 7401-7425

Author version available

Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications

Z. Song, H. Fu, R. Wang, L. A. Pacheco, X. Wang, Y. Lin and J. Cheng, Chem. Soc. Rev., 2018, 47, 7401 DOI: 10.1039/C8CS00095F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements