Issue 11, 2018

A guide to integrating immunohistochemistry and chemical imaging

Abstract

Chemical imaging provides new insight into the fundamental atomic, molecular, and biochemical composition of tissue and how they are interrelated in normal physiology. Visualising and quantifying products of pathogenic reactions long before structural changes become apparent also adds a new dimension to understanding disease pathogenesis. While chemical imaging in isolation is somewhat limited by the nature of information it can provide (e.g. peptides, metals, lipids, or functional groups), integrating immunohistochemistry allows simultaneous, targeted imaging of biomolecules while also mapping tissue composition. Together, this approach can provide invaluable information on the inner workings of the cell and the molecular basis of diseases.

Graphical abstract: A guide to integrating immunohistochemistry and chemical imaging

Article information

Article type
Tutorial Review
Submitted
24 1月 2018
First published
15 3月 2018
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2018,47, 3770-3787

A guide to integrating immunohistochemistry and chemical imaging

D. P. Bishop, N. Cole, T. Zhang, P. A. Doble and D. J. Hare, Chem. Soc. Rev., 2018, 47, 3770 DOI: 10.1039/C7CS00610A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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