Issue 25, 2017

TBHP-promoted direct oxidation reaction of benzylic Csp3–H bonds to ketones

Abstract

A metal-free oxidation system employing tert-butyl hydroperoxide (TBHP) has been developed for selective oxidation of structurally diverse benzylic sp3 C–H bonds. This low-cost methodology allows for rapid generation of synthetically and biologically valued arylketones in good to excellent yields from readily available alkylarenes and diarylmethanes.

Graphical abstract: TBHP-promoted direct oxidation reaction of benzylic Csp3–H bonds to ketones

Supplementary files

Article information

Article type
Paper
Submitted
09 1月 2017
Accepted
27 2月 2017
First published
07 3月 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 15176-15180

TBHP-promoted direct oxidation reaction of benzylic Csp3–H bonds to ketones

J. Tan, T. Zheng, Y. Yu and K. Xu, RSC Adv., 2017, 7, 15176 DOI: 10.1039/C7RA00352H

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