Issue 29, 2023

Development of nanozyme based sensors as diagnostic tools in clinic applications: a review

Abstract

Since 1970, many artificial enzymes that imitate the activity and structure of natural enzymes have been discovered. Nanozymes are a group of nanomaterials with enzyme-mimetic properties capable of catalyzing natural enzyme processes. Nanozymes have attracted great interest in biomedicine due to their excellent stability, rapid reactivity, and affordable cost. The enzyme-mimetic activities of nanozymes may be modulated by numerous parameters, including the oxidative state of metal ions, pH, hydrogen peroxide (H2O2) level, and glutathione (GSH) concentration, indicating the tremendous potential for biological applications. This article delivers a comprehensive overview of the advances in the knowledge of nanozymes and the creation of unique and multifunctional nanozymes, and their biological applications. In addition, a future perspective of employing the as-designed nanozymes in biomedical and diagnostic applications is provided, and we also discuss the barriers and constraints for their further therapeutic use.

Graphical abstract: Development of nanozyme based sensors as diagnostic tools in clinic applications: a review

Article information

Article type
Review Article
Submitted
02 3月 2023
Accepted
18 5月 2023
First published
28 6月 2023

J. Mater. Chem. B, 2023,11, 6762-6781

Development of nanozyme based sensors as diagnostic tools in clinic applications: a review

Waris, A. Hasnat, S. Hasan, S. Bano, S. Sultana, A. O. Ibhadon and M. Z. Khan, J. Mater. Chem. B, 2023, 11, 6762 DOI: 10.1039/D3TB00451A

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