Issue 75, 2022

Recent advances in transition metal-mediated trifluoromethylation reactions

Abstract

Fluorine compounds are known for their abundance in more than 20% of pharmaceutical and agrochemical products mainly due to the enhanced lipophilicity, metabolic stability and pharmacokinetic properties of organofluorides. Consequently, the last decade has seen enormous growth in the incorporation of a trifluoromethyl group into organic motifs. With due significance, this review aims to provide a complete picture of the transition metal-mediated construction of C(sp3, sp2, and sp)–CF3 bonds via C–H/X bond functionalization or addition processes in both aliphatic and aromatic hydrocarbons. Diversified reagents ranging from radical and electrophilic to nucleophilic trifluoromethylating agents and their respective mechanisms have been further deliberated in this comprehensive overview. The comprehensive coverage on this topic is expected to make this review unique and beneficial for further future applications enriching the community towards further improvements in the field of trifluoromethylation reactions, in turn improving the propensity towards further development of agrochemical drugs.

Graphical abstract: Recent advances in transition metal-mediated trifluoromethylation reactions

Article information

Article type
Highlight
Submitted
21 7月 2022
Accepted
26 8月 2022
First published
26 8月 2022

Chem. Commun., 2022,58, 10442-10468

Recent advances in transition metal-mediated trifluoromethylation reactions

D. Mandal, S. Maji, T. Pal, S. K. Sinha and D. Maiti, Chem. Commun., 2022, 58, 10442 DOI: 10.1039/D2CC04082D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements