Issue 31, 2018

Platinum nanoworms for imaging-guided combined cancer therapy in the second near-infrared window

Abstract

Cancer imaging and therapy in the second near-infrared (NIR II) window have gained increasing interest owing to the high light penetration depth and minimal optical scattering in the NIR II region (1000–1350 nm). Meanwhile, integrating multiple diagnostic and therapeutic functions into one simple nanoparticle system is of vital significance for cancer theranostics. Herein, we prepare worm-like platinum (Pt) nanoparticles (Pt nanoworms) in a facile way. The Pt nanoworms with surface modification show long blood circulation, high tumor accumulation, and negligible toxicity. With high optical absorption in the NIR II region and strong X-ray attenuation abilities, the Pt nanoworms serve as a good photoacoustic agent and CT contrast agent. Meanwhile, the tumor growth is completely inhibited by using mild photothermal therapy and radiotherapy due to the photothermally improved hypoxia and Pt increased X-ray absorption. Therefore, our work presents a biocompatible platinum nanoparticle system that is promising in image-guided tumor therapy.

Graphical abstract: Platinum nanoworms for imaging-guided combined cancer therapy in the second near-infrared window

Supplementary files

Article information

Article type
Paper
Submitted
13 6月 2018
Accepted
12 7月 2018
First published
13 7月 2018

J. Mater. Chem. B, 2018,6, 5069-5079

Platinum nanoworms for imaging-guided combined cancer therapy in the second near-infrared window

Q. Ma, L. Cheng, F. Gong, Z. Dong, C. Liang, M. Wang, L. Feng, Y. Li, Z. Liu, C. Li and L. He, J. Mater. Chem. B, 2018, 6, 5069 DOI: 10.1039/C8TB01545G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements