Themed collection Theranostic nanoplatforms for biomedicine

Nanomaterials interact with the gut microbiome, mucus layer, and epithelial cells, influencing immune responses and facilitating transport to distant organs via blood, lymphatic, and neural pathways, impacting intestinal and systemic health.

An overview of the development of biomimetic AIE nanoparticles and their biomedical applications.

In this review, we provide a comprehensive overview and analysis of the current advancements in nanomedicines for targeted pulmonary delivery.

A critical comparison between different types of nanoparticle-based electrochemical biosensors for the detection of various hormones.

Simultaneous hyperthermia and drug delivery with magnetic iron oxide nanogels.

An overview of the advancements in protein nanoparticles for immunotherapy across diseases include cancer and other diseases like influenza, pneumonia, and hepatitis.

Advanced micro/nano fabrication techniques have revolutionized electroporation technology. Electroporation devices with micro/nanostructures mediating safe, precise and controllable electrotransfection continue to adapt to the field of gene therapy.

Graphical abstract of CMNPs delivering different therapeutic agents for enhancing cancer immunotherapy.

Graphical representation of recent advancements in combinatorial anticancer treatment modalities.

This review summarizes the amplification effect of SNAs in various combined therapy treatment strategies and highlights the recent advances of SNAs in clinical translation.

In situ peptide assemblies have attracted considerable attention as promising alternatives in bacterial infection imaging and treatment.

Advances in functional biomaterial designs for assisting CAR-T therapy against solid tumors.

Nanoniosome-based drug codelivery systems have become popular therapeutic instruments, demonstrating tremendous promise in cancer therapy, infection treatment, and other therapeutic domains.

This work explores cutting-edge strategies to enhance nanozyme selectivity, vital for improving diagnostics and treatments, unlocking their full theranostic potential.

Pancreatic cancer is a devastating disease with a low survival rate and limited treatment options and in this context, multifunctional graphene quantum dot-based receptor targeting, drug delivery, and bioimaging possess immense potential to cure pancreatic cancer.

We develop a hierarchically structured hydrogel by supramolecular self-assembly of all-natural building blocks, glycyrrhizic acid and carrageenan, which can serve as responsive active cargo delivery platforms for food and biomedical applications.

The optimal structure of synthetic glycopolymers for GM1 mimetics was determined through Bayesian optimization.

Nanoparticles have emerged as promising theranostic tools for biomedical applications, notably in the treatment of cancers.

A near-infrared aggregation induced-emission luminogen QMT-SFA was designed for sensitive and real-time imaging of sulfatase activity in breast tumor cells and in vivo.

This work reports the development of a high-throughput microfluidic-based platform for the formulation of cell membrane-camouflaged anisotropic gold nanostructures with minimized phagocytic uptake and enhanced cancer cell targeting.

Tuning the synthesis of iron oxide nanoparticles (IONPs) to modulate structural and vacancy defects has shown that IONPs with fewer defects are more suitable for combining MH and PTT with high efficiency.

We increased the accuracy of tumour nanoparticle delivery using real-time ultrasound imaging and slow syringe-pump controlled infusion. This minimises off-target side effects for better and safer melanoma treatment using magnetic hyperthermia.

In this study, our innovative Mito@ZiF-8 system enhances the functionality of isolated mitochondria and reprograms M2 macrophage metabolism upon delivery, ultimately, reducing the tumorigenic potential of breast cancer cells.

The threat of antibiotic-resistent biofilms demands solutions. Silver-coated azithromycin-Soluplus nanoparticles release silver ions for 6+ hours, disrupt biofilms, and enable rapid, sensitive bacterial detection with laser-induced graphene sensors.

Dual modality nanoprobes with enhanced theranostic properties are designed by decoration of gold nanoparticles with osmium complexes for imaging in the near-infrared and singlet oxygen production, leading to new localised therapy approaches.

A novel electrospinning technique for fast and cost-effective roll-to-roll production of nanofiber-coated sutures with smart drug-releasing capability is introduced, enabling advanced wound care.

The controlled growth of stellate silica shells around iron oxide nanoparticles allows the design of novel efficient theranostics for MRI, magnetic hyperthermia and photothermia.

The core of the semi-synthetic magnetic nanoparticle magnetoferritin was doped with cobalt or zinc in order to evaluate its applicability as a nanoagent for intracellular target redistribution or localised heat dissipation via magnetic hyperthermia.

A cocktail of chemotherapeutic SN-38 and 5-FU/FdUMP in [Gd(OH)]²⁺[(SN-38)_0.5(FdUMP)_0.5]²⁻ inorganic-organic hybrid nanoparticles shows promising efficacy on mouse pancreatic cancer cell lines.

Our study shows that intrinsic magnetocrystalline anisotropy plays a critical role in magnetic hyperthermia. Results indicate that even small deviations from spherical shape have an important impact on optimizing SLP.

Double pH-responsive xenopeptides comprising polar ionizable succinoyl tetraethylene pentamine (Stp) motifs and lipophilic ionizable lipoamino fatty acids (LAFs) were recently found to efficiently transfect mRNA and pDNA at low doses.

To develop an inhalable drug delivery system, we synthesized Remdesivir-loaded nanocomposites (RDV NCs) by coating drug-loaded nanoparticles with supramolecular cell-penetrating peptide nanofibers, enhancing uptake and intracellular drug delivery.

ConA-coated QDs allow live-cell labeling of Leptospira, which is a class of pathogenic bacteria causing Leptospirosis.

Overall schematic presentation depicting the anti cancer property of CuNPANP towards melanoma through in vitro and in vivo studies.

We designed a novel class of anti-inflammatory nanomedicines. It exhibited high cytotoxicity to activated macrophages was able to reduce the secretion of pro-inflammatory cytokines and inhibit the Toll-like receptor signaling cascade.

A novel γ-Fe₂O₃@PNIPAm/PAm/CTS hybrid nanogel using a surfactant-free emulsion copolymerization process exhibited temperature- and pH-sensitivity, enabling magnetic targeting and enhancing diagnosis through MRI.

Novel approach for the functionalization of nanodiamonds with Hyaluronic Acid is proposed, utilizing non-covalent anchoring. NDs exhibit improved properties including increased internalization in human adenocarcinoma cells overexpressing CD44 receptor.

The hyaluronic acid modified zeolitic imidazolate framework-8 encapsulating α-galactosylceramide and doxorubicin, can effectively trigger NKT cell-mediated immune responses along with antitumor chemotoxicity.

A chitosan-coated PCL/nano-hydroxyapatite aerogel was integrated with a nanofiber membrane for constructing a GBR material. Such a material can serve as a barrier and exhibit promising potential in terms of antibacterial properties and guidance of bone regeneration.

Nanoformulations decrease systemic toxicity effects of antitumor agents.

An MOC-based cascade nanozyme with relatively definite structures was developed and it scavenged ROS to alleviate renal I/R injury.

Schematic illustration of the construction of coaxial dual-path electrochemical biosensor for highly accurate recognition and detection of lung cancer-derived exosomal PD-L1.

A photo-responsive self-healing hydrogel-mediated photothermal therapy combined with immune checkpoint blockade effectively inhibited the recurrence of resected tumors, offering insights against post-resection breast cancer recurrence.

Sphingomyelinase enzymatic activity destabilises iron oxide nanomicelles and promotes its accumulation in atherosclerosis in vivo.

The SPION@MSN-EPI/pDNA-ZIF-8-PEG-Apt nanocarrier showcases exceptional plasmid stability, drug loading, and controlled release. Its outstanding anti-tumor efficacy through targeted chemo–gene therapy is supported by its imaging traceability.

Engineered peptides on plasmonic nanostructures show a good targeting activity against the immune checkpoint programmed death ligand 1 protein (PD-L1) expressed by tumor cells. SERS signals allow quantitative evaluation of the targeting activity.

Based on atomistic molecular dynamics simulations and machine learning approaches we unveil the binding mechanism of a cyclic-RGD-ligand activated NP (PEGylated-TiO₂) to its receptor protein (integrin-α_Vβ₃) overexpressed in many tumor cells.

The transducing capacity of magnetic nanoparticles for biomarker detection in AC magnetometry lies in a number of modulating parameters. This is assessed through the variations of AC magnetic hysteresis area in absence (black colour, A₀) and presence (violet colour, A) of analytes.

In this study, we developed oxygen-supplying magnetic bead nanozymes that integrate hemoglobin and encapsulate the photosensitizer curcumin, demonstrating reactive oxygen species (ROS)-induced synergistic breast cancer therapy.

Fluorescence correlation spectroscopy and positron emission tomography are used to study the formation of PEI siRNA polyplex nanoparticles and to trace their biological fate at cell level and in vivo.

Blood clotting disorders are among the main causes of death worldwide. Magnetic coagulometry provides a new method to test coagulation in human whole blood ex vivo, offering grounds for the improvement of current methods in research and clinic.

Magnetic iron oxide nanoparticles coated with PNIPMAM polymer can encapsulate protein guests and release them upon (magnetic) heating above 45 °C in the presence of competitor proteins.

The prepared PNAG NPs loaded with SNPs induce cell migration, proliferation, and angiogenesis, thus reducing inflammation and accelerating in vivo wound healing.

Highly colloidally stable upconverting nanoparticles encapsulated in poly(glycerol monomethacrylate) by RAFT miniemulsion polymerization were non-toxic and exhibited antifouling properties.

We developed an improved sonoporation method using nanobubbles, offering potential for noninvasive uses. Our results confirmed that low frequency insonation yields sonoporation outcomes comparable to those achieved with targeted microbubbles.

We first prepared carbonized polymer dots (MA-dots) from metformin and L-arginine to target the tumor cell membrane and mitochondria for antitumor therapy.

MCDGF can regulate the tumor immune microenvironment and suppress tumor growth by combined therapy, promoting the clinical application of disulfiram.

Dual magneto-chemotherapeutic effects on a 3D breast cancer model after 10, 20 and 30 min of treatment.

To improve the photodynamic therapy (PDT) outcomes and the ability to specifically target cancer cells of TiO₂, anatase TiO_2-x and zwitterionic porphyrin polymer-based nanocomposite TiO_2-x@TFPC is used as the enhanced PDT agent for treating cancer.