Issue 76, 2024

Binaphthyl-based chiral covalent organic frameworks for chiral drug separation

Abstract

Separation of racemic drugs is of great importance and interest in chemistry and pharmacology. Here, we report the bottom-up synthesis of the binaphthyl-based chiral covalent organic frameworks (CCOFs), (R)-BHTP-COF. Then, high-performance liquid chromatography (HPLC) columns were prepared using (R)-BHTP-COF as a chiral stationary phase (CSP). Racemic ibuprofen was successfully baseline-separated on (R)-BHTP-COF-based CSP, and achieved excellent selectivity (α = 2.32) and chromatographic resolution (Rs = 3.39) factors. Meanwhile, the separation of six racemic drugs by the (R)-BHTP-COF-packed column exhibited high resolution, selectivity, and durability. The successful applications indicate the great potential of CCOFs as a novel stationary phase for efficient HPLC separation.

Graphical abstract: Binaphthyl-based chiral covalent organic frameworks for chiral drug separation

Supplementary files

Article information

Article type
Communication
Submitted
27 4月 2024
Accepted
16 7月 2024
First published
05 9月 2024

Chem. Commun., 2024,60, 10580-10583

Binaphthyl-based chiral covalent organic frameworks for chiral drug separation

H. Ma, H. Jiang, Z. Yao, J. Tan, Y. Xing, G. Chen and Y. Dong, Chem. Commun., 2024, 60, 10580 DOI: 10.1039/D4CC02028F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements