Issue 35, 2023

Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines

Abstract

Palladium-catalyzed, solvent-dependent intramolecular oxypalladation-triggered domino sequences of internal alkynes bearing tethered nucleophilic carboxylic ester and electrophilic enone functionalities were developed for the chemodivergent synthesis of two completely distinct biologically significant complex molecules including isochromenone-fused benzazepines and isobenzofuranone-fused tetrahydroquinolines/chromanes in a single synthetic operation.

Graphical abstract: Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines

Supplementary files

Article information

Article type
Communication
Submitted
20 3月 2023
Accepted
30 3月 2023
First published
30 3月 2023

Chem. Commun., 2023,59, 5233-5236

Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines

A. Gupta, T. Jandial, M. Karuppasamy, N. Bhuvanesh, S. Nagarajan, C. U. Maheswari and V. Sridharan, Chem. Commun., 2023, 59, 5233 DOI: 10.1039/D3CC01370G

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