Issue 27, 2021

Utilization of ortho-alkynylarylcarbonyl derivatives for creating structurally diverse chemical compounds

Abstract

ortho-Alkynylarylcarbonyl compounds, including ketones, aldehydes, carboxylic acids, carboxylate esters and amides, have served as useful building blocks for synthetic chemists to prepare numerous classes of important molecules. Various synthetic conversions starting from ortho-alkynylarylcarbonyl precursors are made possible by their unique and enabling structures embedded with reactive carbonyl and alkyne functional groups. These functional groups can be converted directly and independently to other compounds by several reactions. This review highlights the use of these compounds as common precursors for the divergent synthesis of valuable molecules. Moreover, these ortho-alkynylarylcarbonyl compounds can be decorated with other functional group tethers which can lead to an even greater diversity of molecular scaffolds.

Graphical abstract: Utilization of ortho-alkynylarylcarbonyl derivatives for creating structurally diverse chemical compounds

Article information

Article type
Review Article
Submitted
31 3月 2021
Accepted
02 6月 2021
First published
02 6月 2021

Org. Biomol. Chem., 2021,19, 5982-5998

Utilization of ortho-alkynylarylcarbonyl derivatives for creating structurally diverse chemical compounds

C. Thongsornkleeb, J. Tummatorn and S. Ruchirawat, Org. Biomol. Chem., 2021, 19, 5982 DOI: 10.1039/D1OB00629K

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