Issue 71, 2021

Prodrug strategy for enhanced therapy of central nervous system disease

Abstract

Central nervous system (CNS) disease is one of the most notorious arch-criminals of human health across the world. Although considerable efforts have been devoted to promote the development of CNS drugs, ideal therapeutical effects are yet far from enough. The blood–brain barrier remains a major player that impedes the full potential of CNS therapeutical agents as it blocks the entry of CNS drugs into the brain. The past few decades have witnessed the upspring of prodrug strategies as a promising method to accelerate CNS drug development. The prodrug strategy with the ability to overcome the formidable blood–brain barrier enhances the delivery to the brain and hence improves the effects of the CNS therapeutics. In this Feature Article, we summarize the reported barriers and strategies for CNS therapeutics and spotlight prodrug design strategies to improve the efficiency of crossing the blood–brain barrier.

Graphical abstract: Prodrug strategy for enhanced therapy of central nervous system disease

Article information

Article type
Feature Article
Submitted
03 6月 2021
Accepted
30 7月 2021
First published
31 7月 2021

Chem. Commun., 2021,57, 8842-8855

Prodrug strategy for enhanced therapy of central nervous system disease

X. Xia, Y. Zhou and H. Gao, Chem. Commun., 2021, 57, 8842 DOI: 10.1039/D1CC02940A

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