An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

T. A. Zeidan; J. T. Trotta; P. A. Tilak; M. A. Oliveira; R. A. Chiarella; B. M. Foxman; Ö. Almarsson; M. B. Hickey

doi:10.1039/C5CE02467F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite†

T. A. Zeidan,*^a J. T. Trotta,^a P. A. Tilak,^a M. A. Oliveira,^a R. A. Chiarella,^a B. M. Foxman,^b Ö. Almarsson ‡^a and M. B. Hickey^a

Author affiliations

* Corresponding authors

^a Alkermes, Inc., 852 Winter Street, Waltham, MA 02451-1420, USA
E-mail: tarek.zeidan@alkermes.com
Fax: +1 781 609 5855
Tel: +1 781 609 6538

^b Department of Chemistry, Brandeis University, 415 South Street, MS 015, Waltham, MA 02454, USA

Abstract

A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.

This article is part of the themed collection: Editor’s Collection: Polymorphism in Molecular Crystals

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C5CE02467F
Article type: Communication
Submitted: 16 12月 2015
Accepted: 12 1月 2016
First published: 13 1月 2016

Download Citation

CrystEngComm, 2016,18, 1486-1488

Permissions

Request permissions

An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

T. A. Zeidan, J. T. Trotta, P. A. Tilak, M. A. Oliveira, R. A. Chiarella, B. M. Foxman, Ö. Almarsson and M. B. Hickey, CrystEngComm, 2016, 18, 1486 DOI: 10.1039/C5CE02467F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

CrystEngComm

An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite†

Abstract

Supplementary files

Article information

Download Citation

Permissions

An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

Social activity

Search articles by author

Spotlight

Advertisements