Copper-catalyzed perfluoroalkylation of propargyl gem-dichlorides

Abstract

Herein, we present a highly efficient copper-catalyzed protocol for transforming propargyl gem-dichlorides into the corresponding chloro-substituted fluoroalkylated allenes. This protocol demonstrates a broad substrate scope and excellent tolerance towards various functional groups. Moreover, the strategy of utilizing the chloro-substituted pentafluoroethylation allenes for multiple transformations has shown significant value in synthetic chemistry.