Issue 38, 2023

Recent strategies of carbon dot-based nanodrugs for enhanced emerging antitumor modalities

Abstract

Nanomaterial-based cancer therapy has recently emerged as a new therapeutic modality with the advantages of minimal invasiveness and negligible normal tissue toxicity over traditional cancer treatments. However, the complex microenvironment and self-protective mechanisms of tumors have suppressed the therapeutic effect of emerging antitumor modalities, which seriously hindered the transformation of these modalities to clinical settings. Due to the excellent biocompatibility, unique physicochemical properties and easy surface modification, carbon dots, as promising nanomaterials in the biomedical field, can effectively improve the therapeutic effect of emerging antitumor modalities as multifunctional nanoplatforms. In this review, the mechanism and limitations of emerging therapeutic modalities are described. Further, the recent advances related to carbon dot-based nanoplatforms in overcoming the therapeutic barriers of various emerging therapies are systematically summarized. Finally, the prospects and potential obstacles for the clinical translation of carbon dot-based nanoplatforms in tumor therapy are also discussed. This review is expected to provide a reference for nanomaterial design and its development for the efficacy enhancement of emerging therapeutic modalities.

Graphical abstract: Recent strategies of carbon dot-based nanodrugs for enhanced emerging antitumor modalities

Article information

Article type
Review Article
Submitted
02 4月 2023
Accepted
25 8月 2023
First published
29 8月 2023

J. Mater. Chem. B, 2023,11, 9128-9154

Recent strategies of carbon dot-based nanodrugs for enhanced emerging antitumor modalities

X. Chu, M. Duan, H. Hou, Y. Zhang, P. Liu, H. Chen, Y. Liu and S. Li, J. Mater. Chem. B, 2023, 11, 9128 DOI: 10.1039/D3TB00718A

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