Issue 10, 2023

Biphasic nature of lipid bilayers assembled on silica nanoparticles and evidence for an interdigitated phase

Abstract

Functionalizing silica nanoparticles with a lipid bilayer shell is a common first step in fabricating drug delivery and biosensing devices that are further decorated with other biomolecules for a range of nanoscience applications and therapeutics. Although the molecular structure and dynamics of lipid bilayers have been thoroughly investigated on larger 100 nm–1 μm silica spheres where the lipid bilayer exhibits the typical Lα bilayer phase, the molecular organization of lipids assembled on mesoscale (4–100 nm diameter) nanoparticles is scarce. Here, DSC, TEM and 2H and 31P solid-state NMR are implemented to probe the organization of 1,2-dipalmitoyl-d54-glycero-3-phosphocholine (DMPC-d54) assembled on mesoscale silica nanoparticles illustrating a significant deviation from Lα bilayer structure due to the increasing curvature of mesoscale supports. A biphasic system is observed that exhibits a combination of high-curvature, non-lamellar and lamellar phases for mesoscale (<100 nm) supports with evidence of an interdigitated phase on the smallest diameter support (4 nm).

Graphical abstract: Biphasic nature of lipid bilayers assembled on silica nanoparticles and evidence for an interdigitated phase

Supplementary files

Article information

Article type
Paper
Submitted
19 11月 2022
Accepted
09 2月 2023
First published
10 2月 2023

Soft Matter, 2023,19, 1882-1889

Biphasic nature of lipid bilayers assembled on silica nanoparticles and evidence for an interdigitated phase

D. Stengel, R. Thai, Y. Li, N. M. Peters and G. P. Holland, Soft Matter, 2023, 19, 1882 DOI: 10.1039/D2SM01517J

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