Issue 45, 2021

Transition metal-catalyzed arylation of unstrained C–C single bonds

Abstract

Carbon–carbon bond activation is one of the most challenging and important research areas in organic chemistry. Selective C–C bond activation of unstrained substrates is difficult to achieve owing to its inert nature and competitive side reactions, but the ubiquitous presence of C–C bonds in organic molecules makes this transformation attractive and of vital importance. Moreover, transition metal-catalyzed arylation of unstrained C–C single bonds can realize the cleavage of old C–C bonds and introduce important aryl groups into the carbon chain to construct new C–C bonds at the same time, providing a powerful and straightforward method to reconstruct the skeleton of the molecules. In recent years, considerable progress has been made in the area of direct arylation of C–C bonds, and β-C elimination or oxidative addition strategies play key roles in these transformations. This review summarizes recent achievements of transition metal-catalyzed arylation of unstrained C–C bonds, demonstrated by various kinds of substrates including alcohol, nitrile and carbonyl compounds, and each example is detailed by its corresponding mechanism, catalytic system and scope of the substrate.

Graphical abstract: Transition metal-catalyzed arylation of unstrained C–C single bonds

Article information

Article type
Review Article
Submitted
31 8月 2021
Accepted
12 10月 2021
First published
14 10月 2021

Org. Biomol. Chem., 2021,19, 9809-9828

Transition metal-catalyzed arylation of unstrained C–C single bonds

Y. Long, W. Zhou, Q. Li and X. Zhou, Org. Biomol. Chem., 2021, 19, 9809 DOI: 10.1039/D1OB01707A

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