Issue 46, 2021

β-Keto acids in asymmetric metal catalysis and organocatalysis

Abstract

β-Keto acids, ideal surrogates of inactive ketones, play an important role in organic synthesis. The asymmetric decarboxylative reaction using β-keto acids is the one which is being studied the most. Herein we present a comprehensive review on this research topic, which is generally classified according to different catalytic systems and chiral induction modes. Additionally, some extended utilities of these methodologies for synthesizing bioactive compounds were also summarized. This review will facilitate the synthetic community to understand the role of β-keto acids in asymmetric reactions, providing many new opportunities for further exploration in this field.

Graphical abstract: β-Keto acids in asymmetric metal catalysis and organocatalysis

Article information

Article type
Review Article
Submitted
28 7月 2021
Accepted
12 10月 2021
First published
12 10月 2021

Org. Biomol. Chem., 2021,19, 10030-10046

β-Keto acids in asymmetric metal catalysis and organocatalysis

W. Qin, M. Subhani, C. Jiang and H. Lu, Org. Biomol. Chem., 2021, 19, 10030 DOI: 10.1039/D1OB01481A

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