Issue 39, 2021

C–H activation reactions of nitroarenes: current status and outlook

Abstract

Ring substitution reactions of nitroarenes remain an under-developed area of organic synthesis, confined to the narrow domains of SNAr and SNArH reactions. While searching for alternative methodologies, we took stock of the C–H activation reactions of nitroarenes which unearthed a variety of examples of nitro directed regioselective C–H functionalization reactions such as ortho-arylation, -benzylation/alkylation, and -allylation, oxidative Heck and C–H arylation reactions on (hetero)aromatic rings. A collective account of these reactions is presented in this review to showcase the existing landscape of C–H activation reactions of nitroarenes, to create interest in this field for further development and propagate this strategy as a superior alternative for ring substitution reactions of nitroarenes. The prospect of merging the C–H activation of nitroarenes with C–NO2 activation, thereby harnessing NO2 as a transformable multitasking directing group, is also illustrated.

Graphical abstract: C–H activation reactions of nitroarenes: current status and outlook

Article information

Article type
Review Article
Submitted
26 7月 2021
Accepted
31 8月 2021
First published
31 8月 2021

Org. Biomol. Chem., 2021,19, 8409-8424

C–H activation reactions of nitroarenes: current status and outlook

S. Sengupta and P. Das, Org. Biomol. Chem., 2021, 19, 8409 DOI: 10.1039/D1OB01455B

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