Issue 36, 2021

Forgotten and forbidden chemical reactions revitalised through continuous flow technology

Abstract

Continuous flow technology has played an undeniable role in enabling modern chemical synthesis, whereby a myriad of reactions can now be performed with greater efficiency, safety and control. As flow chemistry furthermore delivers more sustainable and readily scalable routes to important target structures a growing number of industrial applications are being reported. In this review we highlight the impact of flow chemistry on revitalising important chemical reactions that were either forgotten soon after their initial report as necessary improvements were not realised due to a lack of available technology, or forbidden due to unacceptable safety concerns relating to the experimental procedure. In both cases flow processing in combination with further reaction optimisation has rendered a powerful set of tools that make such transformations not only highly efficient but moreover very desirable due to a more streamlined construction of desired scaffolds. This short review highlights important contributions from academic and industrial laboratories predominantly from the last 5 years allowing the reader to gain an appreciation of the impact of flow chemistry.

Graphical abstract: Forgotten and forbidden chemical reactions revitalised through continuous flow technology

Article information

Article type
Review Article
Submitted
25 7月 2021
Accepted
19 8月 2021
First published
19 8月 2021

Org. Biomol. Chem., 2021,19, 7737-7753

Forgotten and forbidden chemical reactions revitalised through continuous flow technology

A. Bonner, A. Loftus, A. C. Padgham and M. Baumann, Org. Biomol. Chem., 2021, 19, 7737 DOI: 10.1039/D1OB01452H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements