Issue 40, 2021

Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization

Abstract

Electronically unbiased arylcyclopropane functionalization has always been a challenge to organic chemists, and the emergence of donor–acceptor cyclopropanes (DACs) has not only vehemently overshadowed them but still dominates the cyclopropane chemistry. Unlike DACs, the absence of pre-installed functional groups makes it harder for them to activate and participate in a reaction. The field has witnessed considerably slow progress since its inception due to the inherent challenges. There are only a few strategies available to open arylcyclopropanes. Therefore, this work is still in its infancy stage in spite of these materials being one of the earliest known type of cyclopropanes. This review manifests the history, endeavors, and achievements alongside the associated challenges, opportunities, and the need for concerted efforts to accomplish the long-awaited golden age of arylcyclopropanes.

Graphical abstract: Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization

Article information

Article type
Review Article
Submitted
22 7月 2021
Accepted
10 9月 2021
First published
10 9月 2021

Org. Biomol. Chem., 2021,19, 8627-8645

Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization

I. M. Taily, D. Saha and P. Banerjee, Org. Biomol. Chem., 2021, 19, 8627 DOI: 10.1039/D1OB01432C

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