Issue 47, 2021

Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling

Abstract

Indolizine is a nitrogen-containing heterocycle that has a variety of potential biological activities, and some indolizine derivatives with excellent fluorescence properties can even be used as organic fluorescent molecules for biological and material applications. Thus, many approaches for their synthesis have been developed. Among them, radical-induced synthetic approaches are receiving increasing attention owing to their unique advantages, such as efficient heterocycle construction, efficient C–C or C–X bond construction, and high atom- and step-economy. This review systematically examines the current and latest synthetic strategies using radical species or radical intermediates for synthesizing indolizines and their derivatives. This review is classified into two parts based on the type of building blocks used for indolizine ring construction and the type of radical trigger for indolizine derivative construction. We anticipate that this review will provide a deep understanding of this topic, and ultimately help researchers to develop novel approaches for the synthesis of indolizine and its derivatives.

Graphical abstract: Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling

Article information

Article type
Review Article
Submitted
22 7月 2021
Accepted
06 10月 2021
First published
03 11月 2021

Org. Biomol. Chem., 2021,19, 10245-10258

Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling

J. Hui, Y. Ma, J. Zhao and H. Cao, Org. Biomol. Chem., 2021, 19, 10245 DOI: 10.1039/D1OB01431E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements