Room-temperature synthesis of core–shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins

Guo Lin; Chaohong Gao; Qiong Zheng; Zhixian Lei; Huijuan Geng; Zian Lin; Huanghao Yang; Zongwei Cai

doi:10.1039/C7CC00482F

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Room-temperature synthesis of core–shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins†

Guo Lin,^a Chaohong Gao,^a Qiong Zheng,^a Zhixian Lei,^a Huijuan Geng,^a Zian Lin,

*^a Huanghao Yang^a and Zongwei Cai*^b

Author affiliations

* Corresponding authors

^a Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, China
E-mail: zianlin@fzu.edu.cn

^b Partner State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong SAR, P. R. China
E-mail: zwcai@hkbu.edu.hk

Abstract

Core–shell structured magnetic covalent organic frameworks (Fe₃O₄@COFs) were synthesized via a facile approach at room temperature. Combining the advantages of high porosity, magnetic responsiveness, chemical stability and selectivity, Fe₃O₄@COFs can serve as an ideal absorbent for the highly efficient enrichment of peptides and the simultaneous exclusion of proteins from complex biological samples.

This article is part of the themed collection: Most downloaded articles of 2017: Organic and Biological Chemistry

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Article information

DOI: https://doi.org/10.1039/C7CC00482F
Article type: Communication
Submitted: 18 1月 2017
Accepted: 09 3月 2017
First published: 09 3月 2017

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Chem. Commun., 2017,53, 3649-3652

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Room-temperature synthesis of core–shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins

G. Lin, C. Gao, Q. Zheng, Z. Lei, H. Geng, Z. Lin, H. Yang and Z. Cai, Chem. Commun., 2017, 53, 3649 DOI: 10.1039/C7CC00482F

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Chemical Communications

Room-temperature synthesis of core–shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins†

Abstract

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Room-temperature synthesis of core–shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins

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