Issue 17, 2004
From the journal:

Chemical Communications

Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?

Örn Almarsson*a  and  Michael J. Zaworotko*b  

* Corresponding authors

a TransForm Pharmaceuticals, Inc., 29 Hartwell Avenue, Lexington, MA 02421, USA
E-mail: almarsson@transformpharma.com
Fax: +781 863 6519
Tel: +781 674 7894

b Department of Chemistry, University of South Florida, SCA400, 4202 E. Fowler Avenue, Tampa, FL 33620, USA
E-mail: xtal@usf.edu
Fax: +813 974 3203
Tel: +813 974 4129

Abstract

The evolution of crystal engineering into a form of supramolecular synthesis is discussed in the context of problems and opportunities in the pharmaceutical industry. Specifically, it has become clear that a wide array of multiple component pharmaceutical phases, so called pharmaceutical co-crystals, can be rationally designed using crystal engineering, and the strategy affords new intellectual property and enhanced properties for pharmaceutical substances.

Graphical abstract: Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?

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Article information

DOI
https://doi.org/10.1039/B402150A
Article type
Feature Article
Submitted
11 2月 2004
Accepted
26 5月 2004
First published
05 8月 2004

Chem. Commun., 2004, 1889-1896

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Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?

Ö. Almarsson and M. J. Zaworotko, Chem. Commun., 2004, 1889 DOI: 10.1039/B402150A

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