Issue 32, 2021

Unconventional approaches for the introduction of sulfur-based functional groups

Abstract

Organosulfur compounds have a pivotal role in the functionalities of many natural products, pharmaceuticals and organic materials. For these reasons, the search for new methodologies for the formation of carbon–sulfur bonds has been the object of intensive work for organic chemists. However, the proposed strategies suffer from various drawbacks, such as volatility, toxicity, and instability of the sulfur sources or the use of VOC solvents. In this review, we summarise the recent protocols which have the goal of obtaining sulfones, thioethers, thiazines, thiazepines and sulfonamides in an unconventional and/or sustainable way. The use of starting materials less invasive and toxic with respect to the traditional reagents, alternative solvents such as water, ionic liquids or deep eutectic solvents, the exploitation of ultrasound and electrochemistry, increasing the efficiency of the process, are reported. Moreover, representative reaction mechanisms are also discussed.

Graphical abstract: Unconventional approaches for the introduction of sulfur-based functional groups

Article information

Article type
Review Article
Submitted
05 6月 2021
Accepted
20 7月 2021
First published
20 7月 2021

Org. Biomol. Chem., 2021,19, 6926-6957

Unconventional approaches for the introduction of sulfur-based functional groups

A. Lanfranco, R. Moro, E. Azzi, A. Deagostino and P. Renzi, Org. Biomol. Chem., 2021, 19, 6926 DOI: 10.1039/D1OB01091C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements