A concise synthetic approach to parvistemin A and (±)-diperezone

Abstract

A concise synthetic approach to symmetric biquinone skeletons has been developed through a new biomimetic oxidative phenolic coupling of 1,2,4-trihydroxyarenes using K₃[Fe(CN)₆] or FeCl₃ as the oxidant under basic conditions. Merging with the ring expansion process of cyclobutenones, a synthetic strategy to biquinone natural products has been developed. And in the light of this strategy, total syntheses of parvistemin A and (±)-diperezone have been achieved.