Issue 7, 2015
From the journal:

Lab on a Chip

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses†

Chun-Wan Yen,ab   Helena de Puig,c   Justina O. Tam,ab   José Gómez-Márquez,d   Irene Bosch,ab   Kimberly Hamad-Schifferli*ce  and  Lee Gehrke*af  

* Corresponding authors

a Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge MA, USA 02139
E-mail: lgehrke@mit.edu

b Winchester Engineering Analytical Center, Food and Drug Administration, Winchester MA, USA 01890

c Dept. of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
E-mail: schiffer@mit.edu

d MIT Little Devices Lab and the MIT-SUTD International Design Centre, USA

e MIT Lincoln Laboratory, Lexington MA 02420, USA

f Dept. of Microbiology and Immunobiology, Harvard Medical School, Boston 02115, USA

Abstract

Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. Here, we present a platform for multiplexed pathogen detection using multi-colored silver nanoplates. This design requires no external excitation source and permits multiplexed analysis in a single channel, facilitating integration and manufacturing.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

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Article information

DOI
https://doi.org/10.1039/C5LC00055F
Article type
Communication
Submitted
15 1月 2015
Accepted
04 2月 2015
First published
12 2月 2015

Lab Chip, 2015,15, 1638-1641

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Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

C. Yen, H. de Puig, J. O. Tam, J. Gómez-Márquez, I. Bosch, K. Hamad-Schifferli and L. Gehrke, Lab Chip, 2015, 15, 1638 DOI: 10.1039/C5LC00055F

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