Mai A. Mansour, Haya A. Elshafei, Alaa S. Sayed, Aya A. Ashour, Nadia E. Hussein, Marwan M. Abdel Karim, Fares M. Kamel, Nada T. Elsayed, Mahmoud R. Ahmed, Mohamed T. Seleem and Rania M. Gomaa
RSC Adv., 2026,16, 24808-24821
Abstract
The furopyrimidine scaffold is an emerging core incorporated into numerous anticancer agents.
M. A. M. Abdel Reheim, Walid E. Elgammal, Mahmoud S. Bashandy, Mohammed I. A. Hamed, Asmaa M. AboulMagd, Mona G. Khalil, Amr M. Abdou and Rasha A. Hassan
RSC Med. Chem., 2025,16, 3714-3735
Abstract
A series of furo[2,3-d]pyrimidine derivatives were synthesized and evaluated for their antiproliferative activity. Compound 10b revealed potent anticancer activity with mean GI% above 100, and remarkable anticancer activity.
Sanhita Sarkar, Kunal Chakraborty and Rajarshi Samanta
Chem. Commun., 2025,61, 19096-19099
From themed collection:
The Functionalization of Unreactive Carbon-Hydrogen Bonds
Abstract
An efficient one-pot synthesis of furopyridones has been developed via Rh(II)-catalyzed C5–H arylation of 2-pyridones with diazonaphthoquinones, followed by Cu(I)-mediated oxidative C–O bond formation at the C6 position.
Zhichao Lu, Tsung-Yun Wong, Yonghong Gan, Guihui Chen, Dinesh J. Paymode and Cheng-yi Chen
RSC Adv., 2024,14, 5435-5439
Abstract
4-Pyrimidone-2-thioethers can be useful synthetic precursors to densely functionalized pyrimidines, commonly encountered in bioactive molecules.
Mohamed M. Hammouda, Marwa M. Rashed, Khaled M. Elattar and Amany M. A. Osman
RSC Adv., 2023,13, 11600-11634
From themed collection:
2023 Reviews in RSC Advances
Abstract
The current review explores the scope of the synthetic strategies supported by nano-catalysts and biological aspects of heterocycles-integrated pyridopyrimidine scaffolds.