A series of furo[2,3-d]pyrimidine derivatives were synthesized and evaluated for their antiproliferative activity. Compound 10b revealed potent anticancer activity with mean GI% above 100, and remarkable anticancer activity.
An efficient one-pot synthesis of furopyridones has been developed via Rh(II)-catalyzed C5–H arylation of 2-pyridones with diazonaphthoquinones, followed by Cu(I)-mediated oxidative C–O bond formation at the C6 position.
4-Pyrimidone-2-thioethers can be useful synthetic precursors to densely functionalized pyrimidines, commonly encountered in bioactive molecules.
The current review explores the scope of the synthetic strategies supported by nano-catalysts and biological aspects of heterocycles-integrated pyridopyrimidine scaffolds.
An efficient protocol for constructing polycyclic bridged chromano-furopyranones and pyrano-furopyranones (related to bioactive natural products) via bismuth(III)-catalyzed cascade annulation of hydroxy-pyranones and unsaturated γ-ketoesters is presented.