Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFRWT/COX-2 inhibitors with docking studies

Nada Reda, Ahmed Elshewy, Hesham I. EL-Askary, Khaled O. Mohamed and Amira A. Helwa

RSC Adv., 2023, 13, 32296
DOI: 10.1039/D3RA06088H

Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

Abdulrahman M. Saleh, Hazem A. Mahdy, Mohamed Ayman El-Zahabi, Ahmed B. M. Mehany, Mohamed M. Khalifa and Ibrahim H. Eissa

RSC Adv., 2023, 13, 22122
DOI: 10.1039/D3RA04182D

Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors

Daowei Huang, Jixia Yang, Qingwei Zhang, Xiaolei Zhou, Yanbo Wang, Zhenhua Shang, Jianqi Li and Baoyin Zhang

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1467028

N‐Substituted‐5‐ [(2,5‐Dihydroxybenzyl)amino]salicylamides as Lavendustin Analogs: Antiproliferative Activity, COMPARE Analyses, Mechanistic, Docking, ADMET and Toxicity Studies

Hajjaj H. M. Abdu‐Allah, Mohamed K. S. El‐Nagar, Wesam S. Qayed, Ola I. A. Salem, Abdel‐Hamid N. Kafafy, Raafat El‐Awady and Mariam A. Nicola

Chem Biol Drug Des, 2025, 105
DOI: 10.1111/cbdd.70052

Beta-1 Receptor (β1) in the Heart Specific Indicate to Stereoselectivity

Ayyad Rezk Rezk, Mansour Ahmed Mohamed , Nejm Ahmed Mohamed , Hassan Yasser Abdel Allem , Gabr Norhan Hassan and Ayyad Ahmed Rezk

Arch Pharm Pharma Sci, 2024, 8, 082
DOI: 10.29328/journal.apps.1001060

Visible‐Light Induced Trifluoromethylation/Cyclization of Unactivated Alkene‐Bound Quinazolinones

Luqian Zou, Hengyuan Zhao, Xinming Wang, Jun Dong, Chungang Yang, Weiqing Sun, Jianbin Xu and Baomin Fan

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400056

Discovery of new thiazolidine-2,4-dione derivatives as potential VEGFR-2 inhibitors: In vitro and in silico studies

Ibrahim H. Eissa, Hazem Elkady, Mahmoud Rashed, Alaa Elwan, Mohamed Hagras, Mohammed A. Dahab, Mohammed S. Taghour, Ibrahim M. Ibrahim, Dalal Z. Husein, Eslam B. Elkaeed, Hanan A. Al-ghulikah, Ahmed M. Metwaly and Hazem A. Mahdy

Heliyon, 2024, 10, e24005
DOI: 10.1016/j.heliyon.2024.e24005

Pyrimidine: A Privileged Scaffold for the Development of Anticancer Agents as Protein Kinase Inhibitors (Recent Update)

Mai M. Zeid, Osama M. El-Badry, Salwa El-Meligie and Rasha A. Hassan

CPD, 2025, 31, 1100
DOI: 10.2174/0113816128346900241111115125

Recent advancements of pyrimidine chemistry thriving deeper into drug discovery

Glanish Jude Martis, Sneha O, Rajkumar Bhat D and Praveen S. Mugali

Synthetic Communications, 2025, 1
DOI: 10.1080/00397911.2025.2487080