Design, synthesis, biological evaluation, and SAR studies of novel cyclopentaquinoline derivatives as DNA intercalators, topoisomerase II inhibitors, and apoptotic inducers

Mohamed M. Hammoud, Alaa S. Nageeb, M. A. Morsi, Esam A. Gomaa, Ayman Abo Elmaaty and Ahmed A. Al-Karmalawy

New J. Chem., 2022, 46, 11422
DOI: 10.1039/D2NJ01646J

Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents:in silicoandin vitrostudies

Rana M. El-Masry, Ahmed A. Al-Karmalawy, Radwan Alnajjar, Sara H. Mahmoud, Ahmed Mostafa, Hanan H. Kadry, Sahar M. Abou-Seri and Azza T. Taher

New J. Chem., 2022, 46, 5078
DOI: 10.1039/D1NJ04816C

Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1:in vitro, molecular docking, and SAR studies

Eman A. Madbouly, El-Sayed M. Lashine, Ahmed A. Al-Karmalawy, Mahmoud M. Sebaiy, Harris Pratsinis, Dimitris Kletsas and Kamel Metwally

New J. Chem., 2022, 46, 22013
DOI: 10.1039/D2NJ04053K

Rumex Vesicarius L. extract improves the efficacy of doxorubicin in triple-negative breast cancer through inhibiting Bcl2, mTOR, JNK1 and augmenting p21 expression

Aml Ghanem, Ahmed A. Al-Karmalawy, Ahmed I. Abd El Maksoud, Shaden M. Hanafy, Hamdy A. Emara, Rasha M. Saleh and Mohamed F. Elshal

Informatics in Medicine Unlocked, 2022, 29, 100869
DOI: 10.1016/j.imu.2022.100869

Ligand-based design and synthesis of N' -Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro , in vivo, and in silico approaches with SAR studies

Rogy R. Ezz Eldin, Marwa A. Saleh, Mohammad Hayal Alotaibi, Reem K. Alsuair, Yahya A. Alzahrani, Feras A. Alshehri, Amany F. Mohamed, Shaimaa M. Hafez, Azza Ali Althoqapy, Seham K. Khirala, Mona M. Amin, Yousuf A. F, Azza H. AbdElwahab, Mohamed S. Alesawy, Ayman Abo Elmaaty and Ahmed A. Al-Karmalawy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 1098
DOI: 10.1080/14756366.2022.2063282

Traditional medical practices for children in five islands from the Society archipelago (French Polynesia)

François Chassagne, Jean-François Butaud, Raimana Ho, Eric Conte, Édouard Hnawia and Phila Raharivelomanana

J Ethnobiology Ethnomedicine, 2023, 19
DOI: 10.1186/s13002-023-00617-0

Ligand-based design, synthesis, computational insights, and in vitro studies of novel N -(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease

Mohamed Elagawany, Ayman Abo Elmaaty, Ahmed Mostafa, Noura M. Abo Shama, Eman Y. Santali, Bahaa Elgendy and Ahmed A. Al-Karmalawy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 2112
DOI: 10.1080/14756366.2022.2105322

Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies

Howaida I. Abd-Alla, Omnia Kutkat, Heba-tollah M. Sweelam, Wagdy M. Eldehna, Marwa A. Mostafa, Magda T. Ibrahim, Yassmin Moatasim, Mohamed GabAllah and Ahmed A. Al-Karmalawy

Metabolites, 2022, 12, 1109
DOI: 10.3390/metabo12111109

New Phenylthiazoles: Design, Synthesis, and Biological Evaluation as Antibacterial, Antifungal, and Anti‐COVID‐19 Candidates

Inas G. Shahin, Khaled O. Mohamed, Azza T. Taher, Mohamed M. Elsebaei, Abdelrahman S. Mayhoub, Asmaa E. Kassab and Ahmed Elshewy

Chemistry & Biodiversity, 2023, 20
DOI: 10.1002/cbdv.202301143

Decoding chemical profiles and biological activities of aerial parts and roots of Eryngium thorifolium Boiss by HPLC-MS/MS, GC-MS and in vitro chemical assays

Gokhan Zengin, Sakina Yagi, Omayma A. Eldahshan, Abdel Nasser Singab, Selami Selvi, Maria J. Rodrigues, Luisa Custodio, Stefano Dall’Acqua, Sathish Kumar M Ponnaiya and Shaza H. Aly

Food Bioscience, 2024, 61, 104556
DOI: 10.1016/j.fbio.2024.104556

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies

Omnia Kutkat, Yassmin Moatasim, Ahmed A. Al‐Karmalawy, Hamada S. Abulkhair, Mokhtar R. Gomaa, Ahmed N. El-Taweel, Noura M. Abo Shama, Mohamed GabAllah, Dina B. Mahmoud, Ghazi Kayali, Mohamed A. Ali, Ahmed Kandeil and Ahmed Mostafa

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-17082-6

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

Samar El-Kalyoubi, Mohamed M. Khalifa, Mahmoud T. Abo-Elfadl, Ahmed A. El-Sayed, Ahmed Elkamhawy, Kyeong Lee and Ahmed A. Al-Karmalawy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
DOI: 10.1080/14756366.2023.2242714

Comprehensive phytochemical mapping and biomedical evaluation of Lawsonia inermis L: a potential natural treatment for diabetic foot ulcers with wound healing and antimicrobial effects

Safaa M. Kotb, Mai M. Farid, Ahmed A. Al-Karmalawy, Magdy A.H. Zahran, Briksam S. Mohamed, Abdelnaser A. Gadallah and Bishoy El-Aarag

Fitoterapia, 2025, 187, 106939
DOI: 10.1016/j.fitote.2025.106939

Investigation of the phytochemical composition, antioxidant, antibacterial, anti-osteoarthritis, and wound healing activities of selected vegetable waste

Mohamed A. Salem, Osama G. Mohamed, Esraa M. Mosalam, Aya Ibrahim Elberri, Hend Mohamed Abdel-Bar, Mariam Hassan, Ahmed A. Al-Karmalawy, Ashootosh Tripathi, Shahira M. Ezzat and Hend E. Abo Mansour

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-38591-y

Small Steps to the Big Picture for Health‐Promoting Applications Through the Use of Chickweed (Stellaria media): In Vitro, In Silico, and Pharmacological Network Approaches

Gaia Cusumano, Giancarlo Angeles Flores, Mehmet Veysi Cetiz, Umran Kurt, Gunes Ak, Enver Saka, Shaza H. Aly, Omayma A. Eldahshan, Abdel Nasser Singab, Gokhan Zengin, Ismail Senkardes, Maria J. Rodrigues, Luisa Custodio, Carla Emiliani and Paola Angelini

Food Science & Nutrition, 2024, 12, 9295
DOI: 10.1002/fsn3.4505

The Molecular Mechanisms Underlying the Antineoplastic Profile of Vitexin 2″‐O‐α‐L‐Rhamnopyranoside From Cordyline australis (G.Frost.): Isolation and Constituent Profiling

Mona A. Raslan, Marwa M. Mounier and Rehab F. Taher

Archiv der Pharmazie, 2025, 358
DOI: 10.1002/ardp.70054

In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity

Ayman Abo Elmaaty, Khaled M. Darwish, Amani Chrouda, Amira A. Boseila, Mohamed A. Tantawy, Sameh S. Elhady, Afzal B. Shaik, Muhamad Mustafa and Ahmed A. Al-karmalawy

ACS Omega, 2022, 7, 875
DOI: 10.1021/acsomega.1c05519

Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2

Abeer M. El-Naggar, A.M.A. Hassan, Eslam B. Elkaeed, Mohamed S. Alesawy and Ahmed A. Al‐Karmalawy

Bioorganic Chemistry, 2022, 123, 105770
DOI: 10.1016/j.bioorg.2022.105770

Synthesis and Molecular Docking Analysis of New Thiazo-isoindolinedione Hybrids as Potential Inhibitors of the SARS-CoV-2 Main Protease

Saad Shaaban, Ahmed A. Al-Karmalawy, Abdulrahman G. Alhamzani, Mortaga M. Abou–Krisha, Mahmoud A. Al–Qudah and Tarek A. Yousef

Orient. J. Chem, 2023, 39, 913
DOI: 10.13005/ojc/390412

Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies

Ayman Abo Elmaaty, Wagdy Eldehna, Muhammad Khattab, Omnia Kutkat, Radwan Alnajjar, Ahmed El-Taweel, Sara Al-Rashood, Mohammed Abourehab, Faizah Binjubair, Mohamed Saleh, Amany Belal and Ahmed Al-Karmalawy

IJMS, 2022, 23, 12235
DOI: 10.3390/ijms232012235

In-situ self-assembled synthesis by adjusting Ag0 on oxygen-defect rich ZrFe2O4 through electronic metal-support interaction to enhance the mineralization of metronidazole and antimicrobial applications

J.P. Steffy, B. Janani, Alanoud T. Alfagham, Abdallah M. Elgorban and S. Sudheer Khan

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 739, 139976
DOI: 10.1016/j.colsurfa.2026.139976

Ethnobotany, Phytochemistry, and Biological Activities of the Genus Cordyline

Romuald Tematio Fouedjou, Bienvenu Tsakem, Xavier Siwe-Noundou, Hervet P. Dongmo Fogang, Aphalaine Tiombou Donkia, Beaudelaire Kemvoufo Ponou, Madan Poka, Patrick H. Demana, Rémy B. Teponno and Léon Azefack Tapondjou

Biomolecules, 2023, 13, 1783
DOI: 10.3390/biom13121783

Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies

Mohamed M. Hammouda, Ayman Abo Elmaaty, Mohamed S. Nafie, Marwa Abdel-Motaal, Noha S. Mohamed, Mohamed A. Tantawy, Amany Belal, Radwan Alnajjar, Wagdy M. Eldehna and Ahmed A. Al‐Karmalawy

Bioorganic Chemistry, 2022, 127, 105995
DOI: 10.1016/j.bioorg.2022.105995

Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity

Mohamed M. Hammoud, Muhammad Khattab, Marwa Abdel-Motaal, Johan Van der Eycken, Radwan Alnajjar, Hamada S. Abulkhair and Ahmed Ali Al‐Karmalawy

Journal of Biomolecular Structure and Dynamics, 2022, 1
DOI: 10.1080/07391102.2022.2082533

A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways

Mona F. El-Azab, Ahmed A. Al-Karmalawy, Samar A. Antar, Pierre A. Hanna, Karim M. Tawfik and Reem M. Hazem

Life Sciences, 2022, 303, 120691
DOI: 10.1016/j.lfs.2022.120691

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR WT and EGFR T790M inhibitors

Tarfah Al-Warhi, Ahmed A. Al-Karmalawy, Ayman Abo Elmaaty, Maha A. Alshubramy, Marwa Abdel-Motaal, Taghreed A. Majrashi, Medhat Asem, Ahmed Nabil, Wagdy M. Eldehna and Marwa Sharaky

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38, 176
DOI: 10.1080/14756366.2022.2135512

Fabrication of Silver Nanoparticles Using Cordyline fruticosa L. Leave Extract Endowing Silk Fibroin Modified Viscose Fabric with Durable Antibacterial Property

Ngoc-Thang Nguyen and Thi-Lan-Huong Vo

Polymers, 2022, 14, 2409
DOI: 10.3390/polym14122409

In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus

Dalia Elebeedy, Ingy Badawy, Ayman Abo Elmaaty, Moustafa M. Saleh, Ahmed Kandeil, Aml Ghanem, Omnia Kutkat, Radwan Alnajjar, Ahmed I. Abd El Maksoud and Ahmed A. Al-karmalawy

Computers in Biology and Medicine, 2022, 141, 105149
DOI: 10.1016/j.compbiomed.2021.105149