Issue 48, 2024

Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy

Abstract

Luminescent cyclometallated iridium(III) complexes bearing a 2-formylphenylboronic acid moiety were designed; one of the complexes was utilised to modify peptides containing an N-terminal cysteine to afford luminescent conjugates with selective organelle-targeting or furin-responsive properties.

Graphical abstract: Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
17 ⵉⴱⵔ 2024
Accepted
10 ⵎⴰⵢ 2024
First published
10 ⵎⴰⵢ 2024

Chem. Commun., 2024,60, 6186-6189

Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(III) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy

L. Huang, L. C. Lee, J. Shum, G. Xu and K. K. Lo, Chem. Commun., 2024, 60, 6186 DOI: 10.1039/D4CC01824A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements