Issue 9, 2018

Sharp-featured Au@Ag core/shell nanocuboid synthesis and the label-free ultrasensitive SERS detection of protein single-point mutations

Abstract

Sharp-featured Au@Ag core/shell nanocuboids were synthesized. Simulation and experimental results demonstrated that the sharp features and in-cuboid, out-of-cuboid LSPR coupling of the nanocuboids enabled high SERS activities. The ultrasensitive detection of single-point mutations of TDP-43 proteins was demonstrated at 10 pM for the first time. This could be a general strategy for single-point mutation detection in proteins.

Graphical abstract: Sharp-featured Au@Ag core/shell nanocuboid synthesis and the label-free ultrasensitive SERS detection of protein single-point mutations

Supplementary files

Article information

Article type
Research Article
Submitted
24 ⵉⴱⵔ 2018
Accepted
17 ⵢⵓⵍ 2018
First published
18 ⵢⵓⵍ 2018

Mater. Chem. Front., 2018,2, 1720-1724

Sharp-featured Au@Ag core/shell nanocuboid synthesis and the label-free ultrasensitive SERS detection of protein single-point mutations

G. Tu, N. Deogratias, M. Xu, X. Li, J. Liu, L. Jiang, Y. Yang and J. Zhang, Mater. Chem. Front., 2018, 2, 1720 DOI: 10.1039/C8QM00185E

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