Issue 52, 2018

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes

Abstract

A Stille cross-coupling reaction was developed that delivers for the first time trifluoromethyl-substituted homoallyl compounds from α-(trifluoromethyl)benzyl chlorides and allylstannanes. This reaction proceeds even with low catalyst loadings (1 mol%) via a rare CF3–Pd–π-benzyl intermediate.

Graphical abstract: Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes

Supplementary files

Article information

Article type
Communication
Submitted
02 ⵎⴰⵢ 2018
Accepted
04 ⵢⵓⵏ 2018
First published
04 ⵢⵓⵏ 2018

Chem. Commun., 2018,54, 7171-7174

Author version available

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes

N. Punna, K. Harada and N. Shibata, Chem. Commun., 2018, 54, 7171 DOI: 10.1039/C8CC03541E

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