Issue 18, 2016

Highly diastereo-/enantioselective Cu-catalyzed propargylic alkylations of propargyl acetates with cyclic enamines

Abstract

Highly diastereo- and enantioselective copper-catalyzed propargylic alkylations of propargylic acetates with morpholine-derived cyclic enamines for the construction of vicinal tertiary stereocenters have been developed. By the employment of a less sterically hindered chiral tridentate P,N,N-ligand, good to excellent diastereo- (up to >98 : 2 dr) and enantioselectivity (up to 99% ee) could be achieved for a wide range of substrates.

Graphical abstract: Highly diastereo-/enantioselective Cu-catalyzed propargylic alkylations of propargyl acetates with cyclic enamines

Supplementary files

Article information

Article type
Communication
Submitted
02 ⴷⵓⵊ 2015
Accepted
26 ⵉⵏⵏ 2016
First published
28 ⵉⵏⵏ 2016

RSC Adv., 2016,6, 14763-14767

Highly diastereo-/enantioselective Cu-catalyzed propargylic alkylations of propargyl acetates with cyclic enamines

C. Zhang, Y. Hui, D. Zhang and X. Hu, RSC Adv., 2016, 6, 14763 DOI: 10.1039/C5RA25627E

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