Diastereo- and enantioselective synthesis of 1,3,5,7-tetraol structural units using a Prins cyclisation–reductive cleavage sequence

Abstract

Stereocontrolled and efficient access to all the diastereomers of 1,3,5,7-tetraol structural units was developed using a Prins cyclisation–reductive cleavage sequence applied to tetrahydropyran aldehydes. Furthermore, these tetraols can be selectively functionalized.