Issue 62, 2013

Zinc finger peptide cleavage by a dinuclear platinum compound

Abstract

Electrospray ionisation mass spectrometry (ESI-MS) and {1H, 15N HSQC} NMR spectroscopy has elucidated the binding of a dinuclear platinum compound to a zinc finger peptide with induced backbone cleavage. Cleavage is selective on the N-terminal side of the cysteine residue following incubation at neutral pH, and is further dependent on structure of dinuclear compound.

Graphical abstract: Zinc finger peptide cleavage by a dinuclear platinum compound

Supplementary files

Article information

Article type
Communication
Submitted
05 ⵢⵓⵏ 2013
Accepted
18 ⵢⵓⵏ 2013
First published
19 ⵢⵓⵏ 2013

Chem. Commun., 2013,49, 6986-6988

Zinc finger peptide cleavage by a dinuclear platinum compound

J. B. Mangrum, I. Zgani, S. D. Tsotsoros, Y. Qu and N. P. Farrell, Chem. Commun., 2013, 49, 6986 DOI: 10.1039/C3CC44219E

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