Issue 8, 2023

Diruthenium(ii,iii) paddlewheel complexes: effects of bridging and axial ligands on anticancer properties

Abstract

This article provides an overview of the application of diruthenium(II,III) paddlewheel complexes for anticancer purposes. The use of this coordinative construct is indeed attractive because it provides an excellent opportunity to combine the pharmacological properties of the dimetallic ruthenium center with those derived from the specific choice of ligands bearing a carboxylic function capable of coordination towards the Ru–Ru core. Indeed, the combination of carboxylate ligands with specific anticancer properties and the dimetallic center permits the production of new entities endowed with improved biological profiles. Additionally, these systems allow the simultaneous multiple deliveries of a drug to the target site. Nevertheless, in order to obtain the desired effects, it is mandatory to consider some relevant chemico-physical aspects such as the steric hindrance of the ligands or the possibility of their release under specific biological conditions that should be taken into account in the design of effective complexes. Accordingly, through various examples from the literature, the key features of this family of unconventional compounds are summarized here, also providing useful hints for the design of improved diruthenium(II,III) paddlewheel complexes.

Graphical abstract: Diruthenium(ii,iii) paddlewheel complexes: effects of bridging and axial ligands on anticancer properties

Article information

Article type
Review Article
Submitted
23 ⵉⵏⵏ 2023
Accepted
13 ⵎⴰⵕ 2023
First published
15 ⵎⴰⵕ 2023
This article is Open Access
Creative Commons BY-NC license

Inorg. Chem. Front., 2023,10, 2226-2238

Diruthenium(II,III) paddlewheel complexes: effects of bridging and axial ligands on anticancer properties

I. Tolbatov, E. Barresi, S. Taliani, D. La Mendola, T. Marzo and A. Marrone, Inorg. Chem. Front., 2023, 10, 2226 DOI: 10.1039/D3QI00157A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements