An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

Bo Wang; Ximiao Wen; Yan Cao; Shan Huang; Hoa A. Lam; Tingyi “Leo” Liu; Pei-Shan Chung; Harold G. Monbouquette; Pei-Yu Chiou; Nigel T. Maidment

doi:10.1039/D0LC00021C

An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery†

Bo Wang,

‡^ab Ximiao Wen,‡^c Yan Cao,^d Shan Huang,^e Hoa A. Lam,^a Tingyi “Leo” Liu,

^f Pei-Shan Chung,^g Harold G. Monbouquette,

^d Pei-Yu Chiou*^cg and Nigel T. Maidment*^a

Author affiliations

* Corresponding authors

^a Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, California 90095, USA
E-mail: nmaidmen@g.ucla.edu

^b Department of Electrical and Computer Engineering, University of California at Los Angeles, California, USA

^c Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, California 90095, USA
E-mail: pychiou@seas.ucla.edu

^d Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, California, USA

^e Department of Biological Chemistry, University of California at Los Angeles, California, USA

^f Department of Mechanical and Industrial Engineering, University of Massachusetts Amherst, Massachusetts, USA

^g Department of Bioengineering, University of California at Los Angeles, CA 90095, USA

Abstract

A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.

This article is part of the themed collection: Wearable and Implantable Sensors

Lab on a Chip

An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery†

Abstract

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An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

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