Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

Abstract

Developing a simple and degradable synergistic therapy nanosystem based on glucose oxidase (GOx) remains a challenge. Inspired by the chain reactions among silver nanoparticles, GOx and intratumoral glucose, a degradable GOx-conjugated silver nanocube (AgNC–GOx) for synergistic cancer starving-like/metal ion therapy is presented. The combination of glucose depletion, toxic H₂O₂ and Ag ions effectively inhibits tumor growth with minimal adverse effects.