Issue 10, 2018

A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy

Abstract

In this work, a cellular/intranuclear dual-targeting nanoplatform was designed for tumor photothermal therapy (PTT). As a photo-to-heat nanoheater, a gold nanostar (GNS) was decorated with a nuclear localization sequence (NLS) to form GNS-NLS which possessed nuclear-targeting ability. After that, hyaluronic acid (HA) was coated on the surface of GNS-NLS (GNS-NLS@HA) via electrostatic interaction for tumor cellular recognition and targeting. It was found that by harnessing the recognition of CD44 receptor by HA, GNS-NLS@HA had the ability to target tumor cells accurately, and further be efficaciously internalized into cells with stellate shape. Subsequently, tumor intracellular hyaluronidase (HAase) from the endosome led to the degradation of HA to expose nuclear-targeting nanoheater GNS-NLS, and GNS-NLS was able to enhance PTT efficiency through subcellular nuclear location by a dual-stage near infrared light irradiation strategy. The first stage of light irradiation was of short duration to enhance the subcellular location of the nanoplatform to nuclei, and the second stage of light irradiation was of long duration to achieve admirable photothermal transduction as well as destruction of nuclei. This cellular/intranuclear dual-targeting nanoplatform, GNS-NLS@HA, displayed prominent tumor suppression efficiency both in vitro and in vivo, and inhibited tumor metastasis effectively.

Graphical abstract: A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
10 ⵉⵏⵏ 2018
Accepted
13 ⴱⵕⴰ 2018
First published
13 ⴱⵕⴰ 2018

J. Mater. Chem. B, 2018,6, 1543-1551

A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy

S. Chen, J. Fan, W. Qiu, F. Liu, G. Yan, X. Zeng and X. Zhang, J. Mater. Chem. B, 2018, 6, 1543 DOI: 10.1039/C8TB00087E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements