Issue 6, 2018

Copper-catalyzed three-component phosphorylation–peroxidation of alkenes

Abstract

A copper-catalyzed phosphorylation–peroxidation of alkenes has been developed. The three-component protocol provides practical access to multisubstituted β-phosphoryl peroxides by the reactions of P(O)–H compounds, alkenes and tert-butyl hydroperoxide (TBHP). The obtained β-phosphoryl peroxides can be applied to the synthesis of β-phosphoryl epoxides by using lithium bis(trimethylsilyl)amide (LHMDS) as a base.

Graphical abstract: Copper-catalyzed three-component phosphorylation–peroxidation of alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
22 ⵏⵓⵡ 2017
Accepted
20 ⴷⵓⵊ 2017
First published
21 ⴷⵓⵊ 2017

Org. Chem. Front., 2018,5, 972-976

Copper-catalyzed three-component phosphorylation–peroxidation of alkenes

Y. Chen, Y. Chen, S. Lu and Z. Li, Org. Chem. Front., 2018, 5, 972 DOI: 10.1039/C7QO01045A

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