Issue 12, 2018

Chirality in metal-based anticancer agents

Abstract

Chiral natural biological molecules, such as nucleic acids and proteins, guide the research of chiral compounds. Chiral metal-based drugs are currently an interesting and rapidly growing field in anticancer research. This perspective focuses on chiral metal compounds with application in cancer chemotherapy. The different chiral metal-based anticancer agents and the extent to which the chiral resolution affects their biological properties are discussed. This perspective will aid the design of new potent and efficient chiral metal-based anticancer drugs that exploit their unique properties combined with their potential selectivity toward targeted chiral biomolecules.

Graphical abstract: Chirality in metal-based anticancer agents

Article information

Article type
Perspective
Submitted
09 ⵉⵏⵏ 2018
Accepted
07 ⴱⵕⴰ 2018
First published
08 ⴱⵕⴰ 2018

Dalton Trans., 2018,47, 4017-4026

Chirality in metal-based anticancer agents

Y. Wang, H. Huang, Q. Zhang and P. Zhang, Dalton Trans., 2018, 47, 4017 DOI: 10.1039/C8DT00089A

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