Issue 32, 2017

C60@lysozyme: a new photosensitizing agent for photodynamic therapy

Abstract

C60@lysozyme showed significant visible light-induced singlet oxygen generation in water, indicating the potential of this hybrid as an agent for photodynamic therapy. The reactive oxygen species (ROS) concentration generated by C60@lysozyme during irradiation depends on the light source, the irradiation time and the concentration of the hybrid. C60@lysozyme significantly reduced the HeLa cell viability in response to visible light irradiation. The generation of H2O2, due to the photoactivity of C60@lysozyme, causes cell death via easy permeation of hydrogen peroxide through the cell membrane and activation of endogenous ROS production.

Graphical abstract: C60@lysozyme: a new photosensitizing agent for photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
23 ⵎⴰⵕ 2017
Accepted
27 ⵉⴱⵔ 2017
First published
27 ⵉⴱⵔ 2017

J. Mater. Chem. B, 2017,5, 6608-6615

C60@lysozyme: a new photosensitizing agent for photodynamic therapy

A. Soldà, A. Cantelli, M. Di Giosia, M. Montalti, F. Zerbetto, S. Rapino and M. Calvaresi, J. Mater. Chem. B, 2017, 5, 6608 DOI: 10.1039/C7TB00800G

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