Issue 28, 2016

A cascade reaction for the new and direct synthesis of indolofuroquinoxalines

Abstract

The 7H-indolo[3′,2′:4,5]furo[2,3-b]quinoxaline derivatives are synthesized directly from methyl 2-(2-chloro-1H-indol-3-yl)-2-oxoacetate or its N-alkyl derivatives under neutral or mildly acidic conditions. This new one-pot methodology was found to be general and greener as it avoids the use of environmentally harmful POCl3 and strong alkali required for the previously reported method. It is also amenable for scale-up.

Graphical abstract: A cascade reaction for the new and direct synthesis of indolofuroquinoxalines

Supplementary files

Article information

Article type
Paper
Submitted
07 ⴱⵕⴰ 2016
Accepted
19 ⴱⵕⴰ 2016
First published
22 ⴱⵕⴰ 2016

RSC Adv., 2016,6, 23489-23497

A cascade reaction for the new and direct synthesis of indolofuroquinoxalines

S. P. Nikumbh, A. Raghunadh, T. S. Rao, V. N. Murthy, S. C. Joseph, Y. L. N. Murthy and M. Pal, RSC Adv., 2016, 6, 23489 DOI: 10.1039/C6RA03556F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements